Researchers at the U.S. John Wayne Cancer Institute have identified changes in gene activity that take place when healthy colorectal tissue changes into abnormal tissue, and eventual progresses into cancer.
The changes -- possibly due to environmental influences -- were identified using new approaches at the ultramicroscopic level, and are are now being validated in collaboration with a larger investigation of colorectal cancer by a Dutch group, according to a spokeswoman for the institute, which is located at Saint John's Health Center in Santa Monica, Southern California.
The two studies combined could have important implications for helping early identification of the benign tissue changes that develop into colorectal cancer, as well as for prevention and identifying targets for treatment, according to Dave S.B. Hoon, an investigator for the Santa Monica study.
Hoon also is a principal investigator for the Dutch study collaboration, the results of which may be released as soon as this year, according to the John Wayne Cancer Institute.
Source: Xinhua
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