The Party's disciplinary authorities punished more than 160,000 people last year, a 12.5 percent rise from 2011.
Anti-graft investigators also managed to recover 7.83 billion yuan ($1.24 billion).
One of the highest-profile cases involved Bo Xilai, a former member of the Political Bureau of the Communist Party of China Central Committee. The case has been transferred to judicial organs, according to the CPC's Central Commission for Discipline Inspection.
Nearly 4,700 of those punished were higher than county-level officials. Of these, more than 960 were transferred to judicial authorities, commission spokesman Cui Shaopeng said at a news conference on Wednesday.
Cui encouraged whistle-blowing, saying that the authorities will vigorously pursue cases where the names of culprits are revealed.
A number of senior officials fell from grace. Cases involving Liu Zhijun, former minister of railways, Huang Sheng, former vice-governor of Shandong province, and Tian Xueren, former vice-governor of Jilin province, have been transferred to judicial organs, according to Cui.
Li Chuncheng, the former deputy Party chief of Sichuan province, and Zhou Zhenhong, head of the United Front Work Department of the CPC Guangdong Provincial Committee, are still under investigation by the commission, Cui said.
Low-level officials were also charged in cases of corruption involving large amounts of money, Cui said.
Zheng Niansheng, an official from a subdistrict office of Foshan city in Guangdong province, received a suspended death sentence in July 2012. He was convicted of taking bribes of 25.1 million yuan and misappropriating 100 million yuan of public funds.