TEHRAN, May 23 (Xinhua) -- Iran's Supreme Leader Ayatollah Ali Khamenei on Wednesday ruled out the interaction with the U.S., calling it "untrustable" in fulfilling obligations, Khamenei's official website said.

All successive U.S. governments are not bound to their obligations, Khamenei said during a meeting with senior Iranian officials, referring to the U.S. withdrawal from Iran's 2015 nuclear deal.

The United States has "deep enmity with" Iran, he said, adding that Washington intends to "destroy the power factors of the Islamic republic."

"Since the beginning of the Islamic revolution (in 1979), the U.S. has not given up its enmity against the Islamic republic. They have harnessed all political, economic, military and propaganda measures against Iran," Khamenei said.

Meanwhile, the supreme leader pointed out that the U.S. has failed in its all previous plots against Iran in the past four decades.

"Like the cat in Tom and Jerry (animated series), they will lose again," he said.

Khamenei made the remarks two days after a speech by U.S. Secretary of State Mike Pompeo, in which he threatened to impose the toughest sanctions on Iran if the Islamic state does not change its course of action domestically and regionally.

Pompeo urged Tehran to report to the International Atomic Energy Agency about its nuclear program, end proliferation of its missiles, and stop supporting terrorist groups in the Middle East.

Earlier in the day, Iranian Foreign Minister Mohammad Javad Zarif described Pompeo's speech as "illogical with no heads or tails."

"This is an indication of bankruptcy in the U.S. foreign policy," he said.

"Pressure groups which spend more money can influence the course of Washington's foreign policy," Zarif added.

Meanwhile, Iran's Foreign Ministry Spokesman Bahram Qasemi rejected Pompeo's threatening remarks as "absurd and interventionist."

The U.S. seeks to distract the global attention from its "illegal moves" concerning Iran's nuclear deal by threatening and insulting the Iranian nation, he said in a statement.

Iran preserves the right to legally sue the United States over its illegal measures and threats, Qasemi warned.

Earlier this month, U.S. President Donald Trump announced withdrawal from the historic Iran nuclear deal despite the global outcry.

Trump also vowed to impose "the highest level" of economic sanctions on Tehran and punish those having business links with the Islamic republic.